Disulfiram (brand name: Antabuse) is a drug used to reduce or practically stop the rate of urge for alcohol consumption in persons with high sensitivity for alcoholic substances. It operates by restraining the enzyme acetaldehyde dehydrogenase, subduing the alcoholic substances in the body thereby causing the urge for alcoholic consumption to be reduced.
Antabuse contains 250 mg or 500 mg disulfiram in tablets as it’s the main composite, it also comprises of the following:
- Colloidal Silicon Dioxide;
- Magnesium Stearate;
- Microcrystalline Cellulose;
- Sodium Starch Glycolate;
- Stearic Acid;
- Anhydrous Lactose.
Disulfiram drug is one that chemically makes the patient feel high sensitivity against the consumption of alcoholic substances. The high rate of consumption of alcohol of acetaldehyde in the blood vessels generates a complexity of unpleasant signs known as hereinafter as the disulfiram-alcohol reaction. This drug has not been indicated to stop the rate of alcoholic substances from the body.
Disulfiram aids by reducing the rate of reaction of alcohol in the organism. Which causes a bad feeling when taking alcohol and tends to quench the urge for taking alcoholic substances.
Mode of indication, dosage, duration of treatment
Disulfiram obstructs the changes from acetaldehyde to acetic acid, thereby developing strong acetaldehyde, which can be harmful and results in another form of illness. It is more paramount to know that this drug will not completely treat the stoppage of alcohol consumption. It is indicated as prevention of consuming alcoholic substances. Disulfiram should be consumed often to ensure that the chemical reactions go on, thereby reducing the rate of urge for drinking alcohol. It is sold in the form of tablets and taken once in a day. It is extremely whitish in colour, odorless and tasteless. It also contains 250 mg or 500 mg capsules.
Antabuse should not be consumed after taking metronidazole or paraldehyde, or after one has eaten foods or products that contain alcohol.
It is not recommended to be given to persons without their consent to avoid hazardous effects.
Not to be consumed until after 12 hours before taking alcohol.
This drug has lots of implications while consuming it. Within several minutes after alcohol is drunk, a sequence of the following symptoms can occur so it more recommended not to consume alcohol while on the medication:
- Impaired vision;
- Mental confusion;
- Weakness Problems breathing;
When you forget to take a dose of disulfiram, quickly take it closer to the time of the next dose. Do not increase your next dose or consume more than what is recommended.
Overdosing of this drug can lead to:
- Loss of coordination;
- Unusual muscle movements;
- Dizziness, drowsiness;
- Decreased appetite, excitement.
Antibiotics or drugs for HIV, such as ritonavir, metronidazole, or lopinavir, may rise the negative effects of disulfiram if consumed together with the drug. Consuming disulfiram with the antibiotic isoniazid may provoke one to be unsteady on their feet.
Interaction with other drugs
When consuming disulfiram it is very paramount to avoid alcohol-containing substances, such as cough and cold syrups, tonics, elixirs. Consumption of disulfiram with the above medications can lead to severe vomiting, muscle rubs, headaches, and sweating and in subsequent cases, it can cause irregular heart rhythms and trouble breathing.
Dosage forms and strengths
Disulfiram tablets are consumed 1 time in a day in the morning periods. Consuming this drug with food reduces the troubled stomach. It can be recommended for people to take the dosage of 250 mg daily to assure they can tolerate the therapy. Then if not efficient, the dosage can be boosted to 500 mg daily.